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ALPS Puts Twist On Biotech Investing With Medical Breakthrough ETF

Health & Biotech Equities ETFs had an astounding 2014 with the NASDAQ Biotechnology index returning a stellar 34% in 2014 – emerging as the biggest winner among all the sectors. Despite overall valuation concerns in the early phase of the year, the sector moved along strongly on rising merger and acquisition activities, several important product approvals and label expansions, ever-increasing health care spending, an aging population and last but not least Obamacare. In fact, there is likely little chance of the winning momentum snapping in the near term. Rather, health & biotech stocks are constantly giving positive signals as we move ahead into 2015. Sensing this wave, ALPS has recently launched a new type of biotech ETF. However, many investors must have noticed that, of late, there has been a surge of unique product issuances which do not deal with the cap-weighted and regular-themed index, but rather focus on the smart-beta technique or look for some unique concepts. The recently launched health & biotech ETF is also a fresh themed, being the maiden ETF structured to seize the all-important R&D opportunities in the pharma industry. The ALPS Medical Breakthroughs ETF (NYSEARCA: SBIO ) in Focus The fund looks to track the Poliwogg Medical Breakthroughs Index. The fund mostly consists of mid and small caps with a market cap of not below $200 million and not above $5 billion. The index screens the U.S. listed biotech and pharma companies with one or more drugs in Phase II or Phase III FDA clinical trials. Also, the companies need to have cash for 2 years at their normal burn rate. This fund holds 75 stocks with moderate concentration in the top 10 holdings. The top 10 companies hold a 36% share of total net assets. Among individual holdings, top stocks in the ETF include NPS Pharmaceuticals (NASDAQ: NPSP ), Receptos (NASDAQ: RCPT ) and Seattle Genetics (NASDAQ: SGEN ) comprising 4.96%, 4.32% and 4.15%, respectively, of total net assets. The fund charges 50 bps in fees. How Might it Fit in a Portfolio? The fund is an interesting choice for investors seeking to gain exposure to the high potential health & biotech space. As per the portfolio manager for the ALPS ETF Trust, the fund hit the market at an opportune moment when a number of blockbuster drugs from the 1990s and 2000s have been losing patent protection and Big Pharma is struggling to boost its pipelines. The manager further notified that due to time-consuming procedure and an alarming rate of failure for drug development, the big and well-known companies normally rely on new therapies processed by smaller firms that splurge on R&D as compared to large cap stocks. As per the issuer , the earlier-stage firms in the Poliwogg Medical Breakthroughs Index (PMBI) poured in about 2.7% of market cap on R&D, 29% higher than what has been spent by the NASDAQ Biotech index components. Moreover, firms in the PMBI allocated about 2.0% on non-R&D operating expenses relative to 2.6% by the more recognized firms. Can it Succeed? Though the fund is the pioneer in its theme, another brand new product on a similar subject was launched in December in the name of the BioShares Biotechnology Clinical Trials Fund (NASDAQ: BBC ) and the BioShares Biotechnology Products Fund (NASDAQ: BBP ) . BBC tracks the LifeSci Biotechnology Clinical Trials Index to measure the performance of biotechnology companies with a primary product offering that is in a Phase 1, Phase 2 or Phase 3 clinical trial stage of development. These biotechnology clinical trial companies conduct clinical human trials with the ultimate aim of gaining FDA approval. BBP, on the other hand, tracks the LifeSci Biotechnology Products Index to measure the performance of biotechnology companies with a primary product offering that has received U.S. Food and Drug Administration approval. However, both funds charge 85 bps a year giving SBIO an edge to success. Apart from these, the space is fully packed with products being ruled by the $11.8 billion ETF, the SPDR Health Care Select Sector Fund ( XLV ) , and the $7 billion ETF, the iShares Nasdaq Biotechnology Index Fund ( IBB ) . However, thanks to the relatively new theme, we expect the newly launched product to find a solid following among investors.

Zombies, Run! – Six to Start

Zombies, Run! Six to Start Genre: Health & Fitness Price: $3.99 Release Date: February 27, 2012 Autumn 50% off sale! (originally $7.99, now only $3.99) Join 700,000 runners in an epic adventure! You tie your shoes, put on your headphones, take your first steps outside. You’ve barely covered 100 yards when you hear them. They must be close. You can hear every guttural breath, every rattling groan – they’re everywhere. Zombies. There’s only one thing you can do: Run! Zombies, Run! is an ultra-immersive running game and audio adventure, co-created with award-winning novelist Naomi Alderman. We deliver the story straight to your headphones through orders and voice recordings – and when you get back home, you use the supplies you’ve collected while running to build and grow your base. BBC NEWS – “The only way to save yourself is to run for real.” WIRED – “In the style of Runkeeper, with an exciting undead twist.” LIFEHACKER – “A really cool way to get outside and exercise.” CNN – “Turns exercise into a game – a terrifying, terrifying game.” NPR – “It gets you moving!” TIME.COM – “Takes all the fun of a zombie game and funnels it into a fitness app.” WHAT PLAYERS SAY: “Evaded all zombie mobs 🙂 One of my best sprints ever; this app works!” “This game will make you sweat. Perfect junction between game design and run tracker.” “Just tried @zombiesrungame and for the first time in my life I feel truly alive.” WALK, JOG, OR RUN ANYWHERE Zombies, Run! works anywhere and at any speed. You can jog in a park, run along a beach, or walk along a trail. It even works on treadmills! YOU ARE RUNNER 5 Hundreds of lives are counting on you. You’ve got to rebuild your base from a few shivering survivors into a fortified beacon of civilization by collecting critical supplies and avoiding roving zombie hordes. Can you save them and learn the truth about the zombie apocalypse? A WORLD OF STORIES You become the hero in an epic story of humanity’s struggle for survival where your running *really* matters, and there’s a deeper mystery to be uncovered as well. This app includes all 33 missions from Season 1 as well as the first 7 missions from Season 2 — plus a further 57 missions are available for purchase! YOUR OWN MIX Choose your own custom playlists before you start running: the story unfolds in between your tracks through a series of dynamic radio messages and voice recordings. INTERVAL TRAINING – WITH ZOMBIES With our optional ‘Zombie Chases’ mode, you’ll need to increase your speed and work up a sweat if you hear zombies on your tail. That’s right – we’ve made interval training *fun*! VIEW YOUR RUNS ONLINE WITH ZOMBIELINK Register with our free ZombieLink service to view and share your runs online, complete with maps, full run history, and the ability to ‘play back’ zombie chases so you can see how much faster you ran when the living dead were right behind you! Plus you can sync your runs with Runkeeper and export them as GPX files. SHARE RUNS WITH FRIENDS With our new ZombieLink Social feature, you can keep tabs on how your friends are doing online, and also share your runs on Twitter and Facebook. KEEP THE SURVIVORS ALIVE You automatically collect items like medicine, batteries, and ammo while running – but when you’re back home, who needs them more: the soldiers or the doctors? Which buildings need extra defenses? It’s up to you – and the bigger your base, the more missions you can play. NOTES – Requires iOS 6 or above. Works on iPhone 3GS, iPhone 4, iPhone 4S, iPhone 5, and iPod Touch 4th gen and 5th gen. – Continued use of GPS running in the background can dramatically decrease battery life. – Accelerometer mode can dramatically decrease battery life. Follow us on Twitter at http://twitter.com/zombiesrungame Sign up to our mailing list at http://www.zombiesrungame.com © © Six to Start